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Assess frailty status using the Fried Frailty Phenotype, a validated tool for identifying vulnerable older adults at risk for adverse health outcomes.
Based on CES-D questions: "I felt that everything I did was an effort" or "I could not get going"
Men: <29 kg (BMI ≤24), <30 kg (BMI 24.1-28), <32 kg (BMI >28)
Women: <17 kg (BMI ≤23), <17.3 kg (BMI 23.1-26), <18 kg (BMI 26.1-29), <21 kg (BMI >29)
Based on time to walk 15 feet. Men: ≥7 sec (height ≤173 cm) or ≥6 sec (>173 cm)
Women: ≥7 sec (height ≤159 cm) or ≥6 sec (>159 cm)
Men: <383 kcal/week; Women: <270 kcal/week of physical activity
Frailty Score
0 / 5
Frailty Status
Classification:
Clinical Implications:
The Fried Frailty Phenotype, developed by Dr. Linda Fried and colleagues from the Cardiovascular Health Study, is one of the most widely used and validated tools for assessing frailty in older adults. This phenotype identifies frailty as a distinct biological syndrome characterized by decreased physiologic reserve and resistance to stressors.
Each of the five criteria represents a key dimension of the frailty phenotype. Weight loss reflects nutritional decline and sarcopenia. Exhaustion indicates reduced energy and endurance. Weakness (low grip strength) correlates with overall muscle strength. Slowness reflects mobility impairment. Low physical activity demonstrates reduced energy expenditure and deconditioning.
Frailty is associated with a 2-3 fold increased risk of falls, disability, hospitalization, and mortality. Pre-frailty represents a critical window for intervention, as progression to frailty can often be prevented or delayed with appropriate interventions. Studies show that multicomponent exercise programs and nutritional interventions can reverse or improve frailty status.
Multicomponent exercise programs combining resistance training, aerobic exercise, and balance training show the strongest evidence for frailty prevention and reversal. Protein supplementation (1.0-1.2 g/kg/day), vitamin D optimization, and comprehensive geriatric assessment with targeted interventions also demonstrate benefit. Medication review and deprescribing can reduce polypharmacy-related risks.
Frailty is a biological syndrome of decreased reserve and resistance to stressors, while disability refers to difficulty or dependence in performing activities of daily living. Frailty often precedes and predicts disability, but the two conditions are distinct and can occur independently.
Yes, particularly in the pre-frail stage. Studies show that approximately 25-50% of pre-frail individuals can transition back to robust status with targeted interventions. Even in frail individuals, improvements in frailty status are possible with comprehensive, multifaceted interventions including exercise, nutrition, and medication optimization.
Annual screening is recommended for community-dwelling adults aged 65 and older. More frequent assessment (every 3-6 months) is appropriate for pre-frail individuals receiving interventions, after major illness or hospitalization, or when there are noticeable changes in functional status.
Weakness thresholds are stratified by gender and BMI. For men: <29 kg (BMI ≤24), <30 kg (BMI 24.1-28), or <32 kg (BMI >28). For women: <17 kg (BMI ≤23), <17.3 kg (BMI 23.1-26), <18 kg (BMI 26.1-29), or <21 kg (BMI >29). These represent the lowest 20th percentile for each category.
Multicomponent programs work best, combining resistance training (2-3 times/week), aerobic exercise (moderate intensity, 20-30 min, 3-5 times/week), and balance training. Start with low intensity and progress gradually. Chair exercises, resistance bands, and walking programs are safe starting points. Physical therapy guidance is recommended for frail individuals.
Current evidence supports 1.0-1.2 g/kg body weight/day for older adults, with higher amounts (1.2-1.5 g/kg/day) for those who are frail or malnourished. Protein should be distributed throughout the day, with 25-30 grams per meal to optimize muscle protein synthesis. Leucine-rich sources (dairy, meat, soy) are particularly beneficial.
No, though they overlap significantly. Sarcopenia refers specifically to age-related loss of muscle mass and strength, while frailty is a broader syndrome encompassing multiple systems. Sarcopenia can contribute to frailty, and many frail individuals have sarcopenia, but frailty includes additional factors like exhaustion, low activity, and weight loss beyond muscle loss.
Frailty is a strong independent predictor of post-operative complications, increased length of stay, and mortality. However, frailty should inform but not solely determine surgical candidacy. Frailty assessment helps with shared decision-making, allows for prehabilitation interventions, and guides post-operative care planning rather than serving as an absolute contraindication.
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Evaluate age-related muscle mass and strength loss