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Drug dosing recommendations based on kidney function
Many drugs are eliminated by the kidneys. Reduced kidney function leads to drug accumulation, increasing risk of toxicity. Adjustment maintains therapeutic levels while avoiding toxicity.
Most drug dosing recommendations were developed using CrCl (Cockcroft-Gault). Using eGFR may lead to underdosing in some cases. Check individual drug labeling.
Use ideal body weight (IBW) or adjusted body weight if actual weight exceeds 120% of IBW. Using actual weight overestimates CrCl in obesity.
Some drugs are removed by dialysis and require supplemental doses after sessions. Check dialyzability for each medication.
No. These are general guidelines. Clinical judgment, drug levels when available, and patient response should guide therapy. Always verify with current references.
In AKI, creatinine-based equations are unreliable. Monitor drug levels when possible. Consider that function may improve or worsen, requiring frequent reassessment.
This calculator provides general guidance only. Always verify dosing with current prescribing information and clinical pharmacist consultation. Individual patient factors may require different approaches.