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Estimate daily protein excretion without 24-hour urine collection
UPCR (mg/g) = (Urine Protein / Urine Creatinine) × 1000
UPCR in mg/g approximates 24h protein in g/day
Use first morning void when possible. Avoid after heavy exercise. Confirm persistent elevation with repeat testing.
Creatinine excretion is relatively constant throughout the day. Dividing protein by creatinine corrects for urine concentration, making a spot sample equivalent to a 24h collection.
UPCR correlates well with 24h protein (r = 0.93-0.97). UPCR in mg/g roughly equals 24h protein in g/day. Accuracy decreases at extremes of muscle mass.
UACR (albumin) is preferred for diabetic screening and early kidney disease. UPCR (total protein) is better for monitoring known glomerular disease and nephrotic syndrome.
Protein excretion >3.5 g/day (or UPCR >3500 mg/g). It suggests nephrotic syndrome, characterized by edema, hypoalbuminemia, and hyperlipidemia.
Yes. Exercise, fever, UTI, heart failure exacerbation, and orthostatic (postural) proteinuria can cause temporary elevation. Repeat testing is important.
In CKD with proteinuria, typically every 3-6 months. More frequent monitoring during active treatment or disease progression.
Proteinuria is a marker of kidney damage and cardiovascular risk. Persistent proteinuria warrants investigation and treatment to slow CKD progression.