Loading Calculator...
Please wait a moment
Please wait a moment
Calculate the Charlson Comorbidity Index to predict 10-year mortality and assess overall disease burden.
1 Point Each:
2 Points Each:
3 Points:
6 Points Each:
CCI Score
0
Age-Adjusted CCI
0
| Age-Adjusted CCI | 10-Year Survival |
|---|---|
| 0 | 98% |
| 1-2 | 95% |
| 3-4 | 88% |
| 5-6 | 77% |
| ≥7 | 45% |
For each decade of age over 40 years, add 1 point to the comorbidity score to calculate the age-adjusted CCI:
The Charlson Comorbidity Index (CCI) is a widely used method to predict mortality by classifying and weighting comorbid conditions. Originally developed in 1987 by Mary Charlson, it has become one of the most extensively studied comorbidity indices in medical research.
The CCI is used across multiple medical contexts including risk stratification for clinical trials, outcome prediction for surgical procedures, prognostication in chronic disease management, and adjustment for confounding in epidemiological research. Higher scores indicate greater disease burden and lower expected survival.
The age-adjusted CCI provides a comprehensive assessment of both comorbidity burden and age-related mortality risk. A score of 0 indicates minimal comorbidity in a younger patient, while scores of 7 or higher suggest significant disease burden with substantially reduced 10-year survival probability.
When selecting comorbidities, only include conditions that are currently active or have caused significant organ damage. The presence of both diabetes without complications and diabetes with end-organ damage should not be counted twice - use only the higher-weighted condition. Similarly, mild and moderate/severe liver disease are mutually exclusive.
The CCI score reflects only the comorbidity burden based on disease conditions. The age-adjusted CCI adds points based on the patient's age (1 point per decade over 40), providing a more comprehensive mortality risk assessment that accounts for both disease and age.
Yes, the CCI can be used for any age. For patients under 50, no age adjustment points are added, but the comorbidity score still provides valuable information about disease burden and can help predict outcomes.
The survival estimates are based on population-level data and provide general guidance. Individual outcomes vary based on factors not captured by the CCI, including disease severity, treatment quality, socioeconomic factors, and lifestyle choices.
Yes, include all documented conditions even if they are well-controlled with treatment. For example, diabetes managed with medication should still be counted, as should heart failure that is compensated with appropriate therapy.
Moderate to severe liver disease includes cirrhosis with portal hypertension, with or without variceal bleeding. Mild liver disease refers to chronic hepatitis or cirrhosis without portal hypertension. These are mutually exclusive categories.
In research, the CCI is commonly used to adjust for comorbidity when comparing outcomes between groups. It helps control for baseline differences in disease burden, making it easier to isolate the effect of specific interventions or exposures.
Diabetes with end-organ damage includes diabetic retinopathy, nephropathy, or neuropathy. If a patient has diabetes with any of these complications, use the 2-point category rather than the 1-point category for diabetes without complications.
The CCI was developed in the 1980s and may not fully capture modern disease management. It doesn't account for disease severity within categories, and some important conditions like obesity or frailty are not included. Despite these limitations, it remains widely validated and useful.