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Calculate estimated glomerular filtration rate (eGFR) with CKD staging
CKD-EPI 2021 is race-free and most accurate for staging
Normal: M 0.7-1.3 mg/dL | F 0.6-1.1 mg/dL
| GFR Range | Common Adjustments | Examples |
|---|---|---|
| ≥60 mL/min | Usually no adjustment needed | Most drugs at normal doses |
| 30-59 mL/min | Reduce dose or extend interval | Gabapentin, metformin, DOACs |
| 15-29 mL/min | Significant dose reduction | Avoid metformin, adjust antibiotics |
| <15 mL/min | Avoid many renally-cleared drugs | Use dialyzable alternatives |
Most common cause of ESRD. Progressive albuminuria, then declining GFR.
Long-standing hypertension damages small vessels. BP control slows progression.
IgA nephropathy, FSGS, membranous nephropathy. Often presents with proteinuria/hematuria.
The current standard for eGFR calculation. Race-free equation recommended by KDIGO. Most accurate for CKD staging and general use. Reports in mL/min/1.73m² (normalized to body surface area).
Estimates creatinine clearance (CrCl) in mL/min. Requires weight. Still used for drug dosing by FDA labels. Not normalized to BSA. Overestimates GFR in obesity.
All formulas assume stable creatinine. Inaccurate in AKI, muscle wasting, extreme body habitus, or recent meat ingestion. Consider cystatin C-based equations in uncertain cases.
Use CKD-EPI for CKD staging and prognosis. Use Cockcroft-Gault for drug dosing when specified by drug labeling. Both have value in clinical practice.