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Calculate iron saturation (TSAT) and interpret iron status from serum iron, TIBC, and ferritin
Normal: 60-170 µg/dL (varies by lab)
Normal: 250-400 µg/dL
M: 30-300 ng/mL | F: 15-200 ng/mL
| Condition | Iron | TIBC | Saturation | Ferritin |
|---|---|---|---|---|
| Normal | Normal | Normal | 20-45% | Normal |
| Iron Deficiency Anemia | Low ↓ | High ↑ | Low ↓ | Low ↓ |
| Anemia of Chronic Disease | Low ↓ | Low/Normal | Low/Normal | Normal/High ↑ |
| Hemochromatosis | High ↑ | Low/Normal | High ↑ | High ↑ |
| Sideroblastic Anemia | High ↑ | Normal | High ↑ | High ↑ |
| Pregnancy | Low/Normal | High ↑ | Low/Normal | Low/Normal |
Measures iron bound to transferrin in blood. Varies significantly with meals and time of day. Best measured fasting in the morning.
Total Iron Binding Capacity - indirect measure of transferrin. Increases when iron stores are low (body makes more transferrin to capture iron).
Percentage of transferrin occupied by iron. Most useful single test for iron overload screening. Calculate: (Iron/TIBC) × 100.
Reflects iron stores. Best marker for iron deficiency (low ferritin = definite deficiency). Elevated in inflammation, liver disease, making it less reliable for overload.